February 28, 1867

Draft : February 28 , 2008 Learning Permutations with Exponential Weights ∗

We give an algorithm for learning a permutation on-line. The algorithm maintains its uncertainty about the target permutation as a doubly stochastic matrix. This matrix is updated by multiplying the current matrix entries by exponential factors which destroy the doubly stochastic property of the matrix, and an iterative procedure is needed to renormalize the rows and columns. Even though the re...

Denis Parsons Burkitt - 28 February 1911--23 March 1993.

Dmd052597 1867..1874

The primary objective of this study was to determine the in vivo absorption properties of valacyclovir, including the potential for saturable proton-coupled oligopeptide transporter 1 (PepT1)-mediated intestinal uptake, after escalating oral doses of prodrug within the clinical dose range. A secondary aim was to characterize the role of PepT1 on the tissue distribution of its active metabolite,...

Dmd059089 1867..1872

Monoclonal antibodies (mAbs) represent an important class of therapeutic modalities. To optimize their pharmaceutical properties, studies have focused on improving mAb pharmacokinetic/ pharmacodynamic profiles by modulating their interactions with the neonatal Fc receptor (FcRn). The influence of both the chemical and physical properties of IgGs has been examined in the context of FcRn interact...

The 1867 Virgin Island Tsunami

The 1867 Virgin Island Tsunami reached large magnitude on the coasts of the Caribbean Islands. A maximum tsunami height of 10 m was reported for two coastal locations (Deshaies and Sainte-Rose) in Guadeloupe. Modelling of the 1867 tsunami is performed in the framework of the nonlinear shallow-water theory. The directivity of the tsunami wave source in the Caribbean Sea according to the assumed ...